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Jonathan S. Weerakkody
YALE POSTDOC + EXTRACELLULAR VESICLES, NEURODEGENERATION, and TRANSLATIONAL BIOENGINEERING
I develop cell-type-resolved extracellular-vesicle and multi-omic tools for blood-based measurement of neurodegeneration, integrating assay engineering, computational interpretation, and functional validation.
The 3M Framework
Cell-type-resolved extracellular vesicle signals can make neurodegeneration measurable, interpretable, and eventually actionable.
I bring clinical neurology, EV biology, nanoscale assay engineering, and interpretable machine learning into one sequence: measure a cell-type-resolved signal, map it to biology and patient trajectory, then manipulate the mechanism in controlled systems.
The work is already underway through EV enrichment platforms, CNS biomarker studies, EVd3x, and East Rock Diagnostics. I welcome clinical, computational, EV-biology, and translational collaborators.
From platform invention to translational measurement
I develop measurement technologies that make a difficult biological signal accessible: a photocleavable lipid nanoprobe platform for selective EV enrichment and research-stage glial EV signatures for studying progression-associated CNS biology.
They are designed to support careful biomarker development—not to overstate clinical readiness before independent validation.
As co-founder of East Rock Diagnostics, I am helping translate this work into Astroscope™: a research-use platform for enriching astrocyte-derived exosomes from plasma and supporting biopharma studies in patient selection, response analysis, endpoint discovery, and centralized sample analysis.
EVd3x: evidence infrastructure for EV multi-omics
EVd3x organizes source-attributed EV multi-omic evidence into a reviewable path from cargo to pathways, disease context, cell types, interactions, and experimental-validation hypotheses. It establishes the training infrastructure for future EV-specific and cohort models.
A research record built across measurement, computation, and translation
My record spans biomarker discovery, vesicle engineering, biosensing, intellectual property, and scientific leadership—including first-author and co-author work in ACS Nano, Advanced Functional Materials, Small, Biosensors and Bioelectronics, and related venues.
Independent Research Program
I develop cell-type-resolved extracellular-vesicle and multi-omic tools for blood-based measurement of neurodegeneration. The work combines EV enrichment, orthogonal quality control, interpretable models, and functional experiments.
I am a Postdoctoral Associate in Neurology at Yale, Principal Investigator on the Robert E. Leet and Clara Guthrie Patterson Mentored Research Award, Co-PI on the Colton Center for Autoimmunity Award, and Co-Founder of East Rock Diagnostics. I welcome conversations regarding faculty opportunities, invited seminars, and scientific collaboration.
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