Publications & Innovation
Peer-reviewed articles, patents, computational infrastructure, talks, and scientific community-building across EV biology, neurodegeneration, and translational bioengineering.
Peer-reviewed articles
Original studies and translational methods papers spanning EV biomarkers, vesicle engineering, and quantitative biosensing.
Study and optimization of the selectivity of an odorant binding protein-based bioelectronic nose.
Kazzy, M. E., Lalis, M., Hurot, C., Weerakkody, J. S., Mathey, R., Saint-Pierre, C., Buhot, A., Livache, T., Topin, J., Moitrier, L., Belloir, C., Briand, L., and Hou, Y. Biosensors and Bioelectronics, 268:116879, Jan. 2025.
MapWhat this established
Established how molecular-recognition parameters shape selectivity in a bioelectronic sensing system.
Photosensitive nanoprobes for rapid high purity isolation and size-specific enrichment of synthetic and extracellular vesicle subpopulations.
Weerakkody, J. S., Tseng, T., Topper, M., Thoduvayil, S., and Ramakrishnan, S. Advanced Functional Materials, 34(34):2400390, Aug. 2024.
MeasureWhat this established
Established a light-releasable nanoprobe approach for high-purity, size-selective vesicle enrichment from complex samples.
CNS cell-derived exosome signatures as blood-based biomarkers of neurodegenerative diseases.
Park, C., Weerakkody, J. S., Schneider, R., Miao, S., and Pitt, D. Frontiers in Neuroscience, 18:1426700, Jun. 2024.
Measure + MapWhat this established
Synthesized the opportunity and constraints of using CNS cell-derived EV signatures as blood-based windows into neurodegenerative biology.
Rapid quantification of first and second phase insulin secretion dynamics using an in vitro platform for improving insulin therapy.
Thoduvayil, S., Weerakkody, J. S., Sundaram, R. V. K., et al. Cell Calcium, 113:102766, Jul. 2023.
ManipulateWhat this established
Demonstrated a quantitative in-vitro platform for resolving dynamic secretory-vesicle behavior.
Native planar asymmetric suspended membrane for single-molecule investigations: Plasma membrane on a chip.
Sundaram, R. V. K., Bera, M., Coleman, J., Weerakkody, J. S., Krishnakumar, S. S., and Ramakrishnan, S. Small, Dec. 2022.
MeasureWhat this established
Established a native-membrane-on-a-chip platform for controlled single-molecule and membrane-process measurements.
Suspended lipid bilayer: A versatile platform for nextgen drug discovery and biomedical applications.
Ramakrishnan, S., and Weerakkody, J. S. Accounts of Materials Research, Sep. 2022.
Measure + ManipulateWhat this established
Reviewed suspended lipid-bilayer platforms as controllable systems for biomedical measurement and intervention research.
Surfactant-like peptide self-assembled into hybrid nanostructures for electronic nose applications.
Weerakkody, J. S., Kazzy, M. E., Jacquier, E., et al. ACS Nano, Feb. 2022.
MapWhat this established
Demonstrated biohybrid nanostructures for chemical-pattern recognition in an electronic-nose platform.
An overview of artificial olfaction systems with a focus on surface plasmon resonance for the analysis of volatile organic compounds.
Kazzy, M. E., Weerakkody, J. S., Hurot, C., et al. Biosensors, 11(8):244, Aug. 2021.
MapWhat this established
Reviewed artificial-olfaction architectures and the sensing principles needed to convert complex chemical patterns into interpretable signals.
Optical index prism sensitivity of surface plasmon resonance imaging in gas phase: Experiment versus theory.
Weerakkody, J. S., Brenet, S., Livache, T., Herrier, C., Hou, Y., and Buhot, A. The Journal of Physical Chemistry C, 124(6):3756–3767, Jan. 2020.
MeasureWhat this established
Connected theory and experiment to quantify sensitivity limits in gas-phase surface-plasmon-resonance imaging.
Improvement of sensitivity of surface plasmon resonance imaging for the gas-phase detection of volatile organic compounds.
Brenet, S., Weerakkody, J. S., Buhot, A., et al. Talanta, 212:120777, May 2020.
MeasureWhat this established
Improved the measurement sensitivity of surface-plasmon-resonance imaging for volatile compound detection.
Development of an optoelectronic nose based on surface plasmon resonance imaging with peptide and hairpin DNA for sensing volatile organic compounds.
Gaggiotti, S., Hurot, C., Weerakkody, J. S., et al. Sensors and Actuators B: Chemical, 303:127188, Jan. 2020.
MapWhat this established
Developed a molecularly informed optoelectronic nose for resolving volatile-organic-compound patterns.
Photosensitive nanoprobes for rapid high purity isolation and size-specific enrichment of synthetic and extracellular vesicle subpopulations.