01 — Measure
Recover cell-type-enriched CNS EV signals from the crowded street of plasma.
Can a blood draw retain a biologically meaningful view of CNS cell state?
Cell-type-enriched EV capture, analytical rigor, and signal protection.
Recover a defined signal from a crowded biofluid
CNS-derived EV signals enter plasma alongside material from many tissues. The measurement problem is not simply detecting more molecules; it is recovering a cell-type-enriched fraction whose origin and quality can still be interpreted.
Measurement before inference
The program pairs cell-type-enriched capture with orthogonal vesicle characterization, pre-analytical discipline, and cargo-quality gates. Those checkpoints are designed to make downstream molecular results comparable rather than merely interesting.
What the measurement gate asks
Before a signature is modeled, the workflow asks whether the input, enrichment, vesicle population, and cargo are fit for the same question. This makes analytical rigor part of the biological result: if a fraction is not sufficiently defined, it cannot support a cell-state inference.